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KMID : 1130620100060030148
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Journal of Clinical Neurology
2010 Volume.6 No. 3 p.148 ~ p.151
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Behavioral Changes as the Earliest Clinical Manifestation of Progressive Supranuclear Palsy
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Han Hyun-Jeong
Kim Hye-Yun
Park Jong-Ho
Shin Hyung-Woo
Kim Go-Un
Kim Dong-Sun
Lee Eun-Ja
Oh Hwa-Eun
Park Seung-Hye
Kim Yun-Jung
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Abstract
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Background: The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages.
Case Report: A 52-year-old woman, who we initially diagnosed with a behavioral variant of frontotemporal dementia developed parkinsonian features, which then progressed to gait instability and gaze abnormality.
Conclusions: We report herein a pathologically confirmed case of PSP presenting with behavioral changes including agitation and irritability, which eventually led to the cardinal symptoms of progressive supranuclear palsy.
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KEYWORD
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frontotemporal dementia, parkinsonism, progressive supranuclear palsy
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